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Tuesday Trials

This week, I am posting clinical trials taking place in the U.K., for my readers there.  Again, if you do end up participating in one of these trials, please do let us know how things go.

The Talking Sense Communication Programme for Dementia Carers — This study will attempt to determine whether family caregivers of persons with dementia can benefit from a structured training program designed to improve communication skills.  It will be conducted through questionnaires and interviews, with persons recruited through the local NHS.  It is being coordinated by the Speech and Language Therapy Department at St. James Hospital in Portsmouth.

Thinking Fit:  Combined Physical, Cognitive, and Social Treatment in Mild Cognitive Impairment (MCI) — The purpose of this study is to determine how persons with MCI will respond to a combination of physical activity, cognitive exercises via the computer, and group socially-based activities.  After participating in a 26-week program, they will be followed yearly to determine fitness, cognition, quality of life, and conversion to dementia.  It is being coordinated by the North Essex Partnership Foundation NHS Trust.

Multi-centre UK Study of the Acetylcholinesterase Inhibitor Donepezil in Early Dementia Associated with Parkinson’s Disease — This study is designed to determine how the medication Donepezil improves cognitive function, neuropsychiatric burden, and functional ability of people with Parkinson’s disease and mild dementia, as compared to a placebo, after 24 months of treatment.  It will take place at multiple locations.

Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild to Moderate Alzheimer’s Disease — The purpose of this study is to determine the safety and effectiveness of using the drug to treat persons with mild to moderate Alzheimer’s disease.  It will be taking place at multiple locations.

The Effects of Diet on Mood, Cognition, and Appetite — This study was designed to investigate whether a high fat, low carbohydrate diet of at least 2 weeks’ duration can produce changes in mood and behavior.  It is being coordinated by the University of Nottingham.



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